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How PRADAXA Works

PRADAXA reduces the risk of blood clots that can form in your body

PRADAXA is a type of anticoagulant or blood thinner, known as a "direct thrombin inhibitor." A direct thrombin inhibitor is a medicine that lowers the chance of blood clots forming in your body by blocking thrombin—the blood's central clotting agent.


Here’s how PRADAXA works:

AFib
DVT or PE

PRADAXA reduces risk of stroke by reducing
the risk of clots that form in the heart

how PRADAXA works - Atrial Fibrillation

Blood clots are the leading cause of
AFib-related strokes

For people with atrial fibrillation, or AFib, not caused by a heart valve problem, PRADAXA reduces the risk of a blood clot forming in the heart and traveling to the brain, where it can cause a stroke. A stroke caused by a blood clot that reduces blood flow is called an ischemic (is-KEE-mic) stroke.

How clots can form

  • When your heart beats irregularly, it doesn't pump blood as effectively as it should
  • This can cause blood to pool in the upper chambers of your heart (called the atria)
  • This pooling can cause a clot to form in your heart
  • A clot in your heart can break away and travel directly to your brain. There, it can block an artery and cause a stroke

How PRADAXA helps stop clots from forming in your heart

  • PRADAXA is a type of medicine known as a direct thrombin inhibitor
  • PRADAXA works by attaching itself to thrombin—the blood's central clotting agent. This reduces the ability of the thrombin to form a clot. That is why it is so important that you keep taking PRADAXA exactly as prescribed by your doctor. Stopping PRADAXA increases your risk of having a stroke or forming blood clots
  • In a clinical trial, PRADAXA was proven superior to warfarin at reducing risk of stroke in patients with AFib not caused by a heart valve problem

PRADAXA treats blood clots that form in your legs (deep vein thrombosis) and lungs (pulmonary embolism) and reduces the risk of recurrence

Diagram of how PRADAXA works

DVT and PE are serious medical conditions

For people who have been treated with an injectable blood thinner for 5 to 10 days, PRADAXA treats blood clots in the veins of your legs (DVT) or lungs (PE), and reduces the risk of recurrence.

How clots can form

  • Deep vein thrombosis occurs when a blood clot forms in one or more of the deep veins in your body, usually in your legs and thighs
  • Some of the risk factors for developing a blood clot include:
    • staying still for a long period of time
    • injury to your veins
    • surgery and certain medicines given during surgery
    • taking birth control pills or hormone replacement therapy
    • pregnancy
    • personal or family history of DVT or PE
    • blood clotting disorders
    • being overweight
    • being over 60 years of age, although DVT or PE can develop at any age
    • cancer
    • smoking
    • heart failure
    • inflammatory bowel disease
    • pacemaker or catheter
  • DVT is a serious condition, especially if it leads to a pulmonary embolism (PE). When a blood clot becomes lodged in a pulmonary artery in the lungs, it is a medical emergency that can be fatal

How PRADAXA helps reduce the risk of clot formation in the veins of your legs and lungs

  • PRADAXA is a type of medicine known as a direct thrombin inhibitor
  • PRADAXA works by attaching itself to thrombin—the blood's central clotting agent. This reduces the ability of the thrombin to form a clot. That is why it is so important that you keep taking PRADAXA exactly as prescribed by your doctor. Stopping PRADAXA increases your risk of developing DVT and PE
  • In clinical trials, PRADAXA was proven as effective as warfarin for treatment of DVT and PE in patients who had already been on an injectable blood thinner for 5 to 10 days. PRADAXA was also proven as effective as warfarin in reducing the risk of recurrence of DVT and PE in patients who have been previously treated

Do you know how PRADAXA
compares to warfarin?

Discover the differences

IMPORTANT SAFETY INFORMATION AND USE OF PRADAXA

For people taking PRADAXA for atrial fibrillation: Do not stop taking PRADAXA without talking to the doctor who prescribes it for you. Stopping PRADAXA increases your risk of having a stroke. PRADAXA may need to be stopped prior to surgery or a medical or dental procedure. Your doctor will tell you when you should stop taking PRADAXA and when you may start taking it again. If you have to stop taking PRADAXA, your doctor may prescribe another medicine to help prevent a blood clot from forming.

PRADAXA can cause bleeding which can be serious and sometimes lead to death. Don’t take PRADAXA if you:

  • currently have abnormal bleeding;
  • have ever had an allergic reaction to it;
  • have had or plan to have a valve in your heart replaced

Your risk of bleeding with PRADAXA may be higher if you:

  • are 75 years old or older
  • have kidney problems
  • have stomach or intestine bleeding that is recent or keeps coming back or you have a stomach ulcer
  • take other medicines that increase your risk of bleeding, like aspirin products, non-steroidal anti-inflammatory drugs (NSAIDs) and blood thinners
  • have kidney problems and take dronedarone (Multaq®) or ketoconazole tablets (Nizoral®)

Call your doctor or seek immediate medical care if you have any of the following signs or symptoms of bleeding:

  • any unexpected, severe, or uncontrollable bleeding; or bleeding that lasts a long time
  • unusual or unexpected bruising
  • coughing up or vomiting blood; or vomit that looks like coffee grounds
  • pink or brown urine; red or black stools (looks like tar)
  • unexpected pain, swelling, or joint pain
  • headaches and feeling dizzy or weak

Spinal or epidural blood clots (hematoma). People who take PRADAXA and have medicine injected into their spinal and epidural area, or have a spinal puncture have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis). Your risk of developing a spinal or epidural blood clot is higher if:

  • a thin tube called an epidural catheter is placed in your back to give you certain medicine
  • you take NSAIDs or a medicine to prevent blood from clotting
  • you have a history of difficult or repeated epidural or spinal punctures
  • you have a history of problems with your spine or have had surgery on your spine.

If you take PRADAXA and receive spinal anesthesia or have a spinal puncture, your doctor should watch you closely for symptoms of spinal or epidural blood clots. Tell your doctor right away if you have back pain, tingling, numbness, muscle weakness (especially in your legs and feet), loss of control of the bowels or bladder (incontinence).

Take PRADAXA exactly as prescribed. It is important to tell your doctors about all medicines (prescription and over‑the‑counter), vitamins, and supplements you take. Some medicines may affect the way PRADAXA works.

PRADAXA can cause indigestion, stomach upset or burning, and stomach pain.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-10881-800-FDA-1088.

What is PRADAXA?

PRADAXA is a prescription blood thinner medicine that lowers the chance of blood clots forming in your body.
PRADAXA is used to:

  • reduce the risk of stroke and blood clots in people who have a medical condition called atrial fibrillation not caused by a heart valve problem. With atrial fibrillation, part of the heart does not beat the way it should. This can lead to blood clots forming and increase your risk of a stroke.
  • treat blood clots in the veins of your legs (deep vein thrombosis) or lungs (pulmonary embolism) and reduce the risk of them occurring again.

PRADAXA is not for use in people with artificial (prosthetic) heart valves.

Please see full Prescribing Information and Medication Guide.

The health information contained in this Website is provided for educational purposes only and is not intended to replace discussions with a healthcare professional. All decisions regarding patient care must be made with a healthcare professional, considering the unique characteristics of the patient.

Boehringer Ingelheim Pharmaceuticals, Inc. either owns or uses the trademarks Pradaxa®, PRADAXA with associated design ®, SolutionsPlus® and related images under license. Other referenced trademarks are owned by third parties.

This site is intended for U.S. residents only. Products discussed herein may have different names and labeling in different countries.

Use of this site is subject to the Internet Site Legal Notices and Disclaimers and Privacy Notice

Copyright © 2016 Boehringer Ingelheim Pharmaceuticals, Inc. All Rights Reserved. [10/16]

PC-PX-0236-CONS

SEE MORE

Important safety information and use of PRADAXA

For people taking PRADAXA for atrial fibrillation: Do not stop taking PRADAXA without talking to the doctor who prescribes it for you. Stopping PRADAXA increases your risk of having a stroke. PRADAXA may need to be stopped prior to surgery or a medical or dental procedure. Your doctor will tell you when you should stop taking PRADAXA and when you may start taking it again. If you have to stop taking PRADAXA, your doctor may prescribe another medicine to help prevent a blood clot from forming.

PRADAXA can cause bleeding which can be serious and sometimes lead to death. Don’t take PRADAXA if you:

  • currently have abnormal bleeding;
  • have ever had an allergic reaction to it;
  • have had or plan to have a valve in your heart replaced

Your risk of bleeding with PRADAXA may be higher if you:

  • are 75 years old or older
  • have kidney problems
  • have stomach or intestine bleeding that is recent or keeps coming back or you have a stomach ulcer
  • take other medicines that increase your risk of bleeding, like aspirin products, non-steroidal anti-inflammatory drugs (NSAIDs) and blood thinners
  • have kidney problems and take dronedarone (Multaq®) or ketoconazole tablets (Nizoral®)

Call your doctor or seek immediate medical care if you have any of the following signs or symptoms of bleeding:

  • any unexpected, severe, or uncontrollable bleeding; or bleeding that lasts a long time
  • unusual or unexpected bruising
  • coughing up or vomiting blood; or vomit that looks like coffee grounds
  • pink or brown urine; red or black stools (looks like tar)
  • unexpected pain, swelling, or joint pain
  • headaches and feeling dizzy or weak

Spinal or epidural blood clots (hematoma). People who take PRADAXA and have medicine injected into their spinal and epidural area, or have a spinal puncture have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis). Your risk of developing a spinal or epidural blood clot is higher if:

  • a thin tube called an epidural catheter is placed in your back to give you certain medicine
  • you take NSAIDs or a medicine to prevent blood from clotting
  • you have a history of difficult or repeated epidural or spinal punctures
  • you have a history of problems with your spine or have had surgery on your spine.

If you take PRADAXA and receive spinal anesthesia or have a spinal puncture, your doctor should watch you closely for symptoms of spinal or epidural blood clots. Tell your doctor right away if you have back pain, tingling, numbness, muscle weakness (especially in your legs and feet), loss of control of the bowels or bladder (incontinence).

Take PRADAXA exactly as prescribed. It is important to tell your doctors about all medicines, vitamins, and supplements you take. Some medicines may affect the way PRADAXA works.

PRADAXA can cause indigestion, stomach upset or burning, and stomach pain.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-10881-800-FDA-1088

What is PRADAXA?

PRADAXA is a prescription blood thinner medicine that lowers the chance of blood clots forming in your body. PRADAXA is used to:

  • reduce the risk of stroke and blood clots in people who have a medical condition called atrial fibrillation not caused by a heart valve problem. With atrial fibrillation, part of the heart does not beat the way it should. This can lead to blood clots forming and increase your risk of a stroke.
  • treat blood clots in the veins of your legs (deep vein thrombosis) or lungs (pulmonary embolism) and reduce the risk of them occurring again.

PRADAXA is not for use in people with artificial (prosthetic) heart valves.

Please see full Prescribing Information and Medication Guide.

The health information contained in this Website is provided for educational purposes only and is not intended to replace discussions with a healthcare professional. All decisions regarding patient care must be made with a healthcare professional, considering the unique characteristics of the patient.

Boehringer Ingelheim Pharmaceuticals, Inc. either owns or uses the trademarks Pradaxa®, PRADAXA with associated design ®, SolutionsPlus® and related images under license. Other referenced trademarks are owned by third parties.

This site is intended for U.S. residents only. Products discussed herein may have different names and labeling in different countries.

Use of this site is subject to the Internet Site Legal Notices and Disclaimers and Privacy Notice

Copyright © 2015 Boehringer Ingelheim Pharmaceuticals, Inc. All Rights Reserved. [12/15]

PC-PXD-0219-CONS